MOLECULAR INTERACTION OF TPPP WITH PRP ANTAGONIZED THE CYTOPRP-INDUCED DISRUPTION OF MICROTUBULE STRUCTURES AND CYTOTOXICITY.

Molecular interaction of TPPP with PrP antagonized the CytoPrP-induced disruption of microtubule structures and cytotoxicity.

BACKGROUND: Tubulin polymerization promoting protein/p25 (TPPP/p25), known as a microtubule-associated protein (MAP), is a brain-specific unstructured protein with a DOUBLE GINGER TEA physiological function of stabilizing cellular microtubular ultrastructures.Whether TPPP involves in the normal functions of PrP or the pathogenesis of prion disease

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Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism

Abstract Background B-type lamins are critical nuclear envelope proteins that interact with the three-dimensional genomic architecture.However, identifying the direct roles of Ladies Jeans B-lamins on dynamic genome organization has been challenging as their joint depletion severely impacts cell viability.To overcome this, we engineered mammalian c

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Gastric Calcifying Fibrous Tumour

Intramucosal gastric tumours are most commonly found to be gastrointestinal stromal tumours or Baby Bib leiomyomas (smooth muscle tumours); however, a variety of other uncommon mesenchymal tumours can occur in the stomach wall.A rare benign calcifying fibrous tumour is reported and the WF Signature Series endoscopic appearance, ultrasound findings

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Multi-level agent architecture for war games

The complexity of war games poses challenges for single-technique-built agents, as it requires balancing between coarse-grained strategic adjustments and fine-grained action Door Mats control, thus limiting agent performance.To address this, this paper proposes a multi-level agent architecture for military strategy games based on the "Intent-Task-A

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